Elaine (also Elaina or Elayne) could refer to:
- Elaine (teacher), a teacher at Lenox High School
- Elaina Vescio, a Starfleet captain in the 2360s
- Elaine Grigsby, a security officer on the USS Enterprise-E
- Elaine Johnson, Robert Johnson's wife
- Elaine Kucera, a Starfleet admiral in the 2270s
- Elaine Mello, a Starfleet captain in the 2360s and 2370s
- Elaine Tucker, Charles Tucker III's mother
- Elaine Watley, an historian on the USS Enterprise
- Elaine Welsh, an architect
- Elayne, a medical technician aboard the USS Enterprise in the 2260s
- Elayne (bistro), an employee at a French bistro
- Elayne (elephant), an African elephant known to Nyota Uhura
- Elayne Granada, an officer aboard the USS Enterprise in the 2280s
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